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Brood of vipers - a Christian perspective
John reserved his harshest words for the religious leaders of his day, who he called a "brood of vipers." Their hypocrisy and adherence to man-made religion made them enemies of his message of freedom.

http://biblegateway.com/passage/?search=Matthew%203:7&version=NIV

Pharisees in the Bible: Matthew 3:7
John the baptist and Jesus didn't have much good to say about the Pharisees, the religious rulers who hounded him with continual efforts to trip up his ministry. Here John calls them a "brood of vipers"--an apt description.

http://biblegateway.com/passage/?search=Matthew%203:7&version=NIV