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Today's Devotional: How Does Knowledge Affect Faith?
In the Gospels, Thomas famously doubts Jesus' resurrection. Thomas even went so far as to say...

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Lack of knowledge - a Christian perspective
A deliberate rejection of God's instruction is a rejection of knowledge itself. And without God's guidance, there's nothing to keep people from being spiritually destroyed.

http://biblegateway.com/passage/?search=Hosea%204:6&version=NIV

Study in the Bible: John 5:37-40
Can knowledge of the Bible save us? Not according to this passage, where it's made clear that just knowing the Scriptures isn't enough to find salvation. It's possible to have a head full of knowledge but a heart that's closed to God.

http://biblegateway.com/passage/?search=John%205:37-40&version=NIV

What about people who have never heard of Christ? - Faith Facts
The Bible makes it clear that through nature and conscience each person has some knowledge about God and sin for which he is accountable. Look at how we are confident that God will not hold anyone accountable for any knowledge he did not receive and yet see how Christ is the only way to salvation.

http://faithfacts.org/search-for-truth/questions-of-christians/what-about-people-who-ha...

Knowledge - Into Thy Word Ministries
Knowledge is being assured that what Christ did is relevant and impacting, and is a reality that must be accepted and committed to. “For by the grace given me I say to every one of you: Do not think of yourself more highly than you ought, but rather think of yourself with sober...

http://70030.netministry.com/articles_view.asp?articleid=32738&columnid=3881